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《医学前沿(英文)》 2012年 第6卷 第4期 页码 411-415 doi: 10.1007/s11684-012-0226-2
Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patients and tramadol possesses potential antidepressant effects. Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-related kinase B (TrkB) is a high affinity catalytic receptor for BDNF. We hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects with significant changes in hippocampal BDNF and TrkB levels in rats. Immobility time of rats receiving different treatment in the forced swimming test (FST) was observed. Levels of BDNF and TrkB in hippocampus were measured by enzyme linked immunosorbent assay. Results showed that tramadol (5 mg/kg) administrated alone neither elicited antidepressant effects nor altered BDNF or TrkB level. However, pretreatment with tramadol (5 mg/kg) enhanced the ketamine (10 mg/kg) -elicited antidepressant effects and upregulated the BDNF and TrkB levels in hippocampus. In conclusion, tramadol pretreatment reinforces the ketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat hippocampus.
关键词: tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B
XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing
《医学前沿(英文)》 2007年 第1卷 第2期 页码 200-206 doi: 10.1007/s11684-007-0038-y
Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 431-436 doi: 10.1007/s11684-009-0088-4
关键词: tanshinone II A myocardial hypertrophy rat protein kinase B abdominal aorta coarctation
《医学前沿(英文)》 2022年 第16卷 第6期 页码 883-895 doi: 10.1007/s11684-022-0919-0
关键词: osteosarcoma autophagy metastasis drug resistance Beclin1 LC3B
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《医学前沿(英文)》 2015年 第9卷 第2期 页码 134-138 doi: 10.1007/s11684-015-0396-9
Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on bypass track resistance, which involves the activation of alternate signaling molecules by tumor cells to bypass inhibition and maintain signaling output, and consider the problems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.
关键词: targeted therapy drug resistance receptor tyrosine kinases cancer
Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 481-489 doi: 10.1007/s11684-016-0494-3
The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase. LKB1 plays crucial roles in cell differentiation, proliferation, and polarity. In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated using Pax2-Cre mice to investigate the function of LKB1 in inner ear hair cells during early embryonic period. LKB1Pax2 CKO mice died perinatally. Immunofluorescence and scanning electron microscopy revealed that stereociliary bundles in LKB1Pax2 CKO mice were clustered and misoriented, respectively. Moreover, ectopic distribution of kinocilium bundles resulting from abnormal migration of kinocilium was observed in the mutant mice. The orientation of stereociliary bundles and the migration of kinocilia are critical indicators of planar cell polarity (PCP) of hair cells. LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during embryonic development. Our results suggest that LKB1 is required in PCP formation in cochlear hair cells in mice.
关键词: LKB1 stereociliary bundles kinocilium planar cell polarity hearing mice
Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis
Vocciante, B. Fabiano
《化学科学与工程前沿(英文)》 2018年 第12卷 第4期 页码 878-892 doi: 10.1007/s11705-018-1744-5
关键词: photocatalysis visible light bismuth compounds nanotechnology environmental remediation decontamination pollution abatement
Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
《医学前沿(英文)》 2021年 第15卷 第3期 页码 495-505 doi: 10.1007/s11684-020-0790-9
关键词: hepatitis B virus-related liver failure traditional Chinese medicine liver regeneration liver regeneration microenvironment cytokines
Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase
Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 232-237 doi: 10.1007/s11705-012-1286-1
关键词: connective tissue mitogen activated protein kinase (MAPK) p38 JNK
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 70-76 doi: 10.1007/s11684-011-0119-9
Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.
关键词: protein kinase C ? signal transduction neurogenic disease
Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 383-388 doi: 10.1007/s11684-016-0488-1
The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.
LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing
《医学前沿(英文)》 2008年 第2卷 第3期 页码 235-238 doi: 10.1007/s11684-008-0044-8
关键词: hyperphosphorylation PP2A activity cellular regulation siRNA siRNA transfection
Projections of heat-related excess mortality in China due to climate change, population and aging
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1732-y
● Four scenarios were used to project heat-related excess mortality in China.
Effects and mechanisms of acupuncture on women related health
《医学前沿(英文)》 doi: 10.1007/s11684-023-1051-5
Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 33-42 doi: 10.1007/s11684-019-0735-3
关键词: cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review
标题 作者 时间 类型 操作
reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-relatedkinase B in rat hippocampus
null
期刊论文
Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive
XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing
期刊论文
Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial
Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,
期刊论文
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance
期刊论文
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
null
期刊论文
Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis
Vocciante, B. Fabiano
期刊论文
medicine regulating liver regeneration” treatment plan for reducing mortality of patients with hepatitis B-related
Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
期刊论文
Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase
Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN
期刊论文
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
期刊论文
Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation
LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing
期刊论文
Projections of heat-related excess mortality in China due to climate change, population and aging
期刊论文